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DeCS
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Descriptor English:
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Genes, BRCA2
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Descriptor Spanish:
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Genes BRCA2
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Descriptor Portuguese:
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Genes BRCA2
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Synonyms English:
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BRCA2 Gene
BRCA2 Genes
Gene, BRCA2
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Tree Number:
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G05.360.340.024.340.375.249.105
G05.360.340.024.340.415.400.105
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Definition English:
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A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human chromosome 13 at locus 13q12.3. Mutations in this gene predispose humans to breast and ovarian cancer. It encodes a large, nuclear protein that is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements. (from Genes Dev 2000;14(11):1400-6) |
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Indexing Annotation English:
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BRCA stands for "BReast CAncer"
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See Related English:
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BRCA2 Protein
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History Note English:
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2002
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Allowable Qualifiers English:
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Record Number:
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36331
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Unique Identifier:
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D024522
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Occurrence in VHL:
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Similar:
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DeCS
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